Penetration power of DMI is another key advantage when using DMI, because it not only improves penetration of actives into the skin but also, it helps the . Dimethyl isosorbide is mainly used as a solvent because it is not only water-soluble but also soluble in some of the organic solvents and oils. 500kg, air transportation is generally recommended, usually called FOB, CFR or CIF service; 3.>500kg, sea freight is generally recommended, usually called FOB, CFR or CIF service; 4. Dimethyl isosorbide is mainly used as a solvent because it is not only water-soluble but also soluble in some of the organic solvents and oils. Product Name Isosorbide Dimethyl Ether Buy In Stock CAS 5306-85-4 Tel Email 2853109658@qq.com Mobile 13371865682 QQ 2853109658 Descriptions: Isosorbide Dimethyl Ether 97% yuanye S73194 Other solubilities: soluble in alcohols: Specific Gravity: 1.17: Specific Rotation Condition &plus;96.1 (21C c&equals;2,CHCl 3) Specific Rotation &plus; 96.10: Formula Weight: 174.19: Physical Form: Liquid: Percent Purity: 99%: Chemical Name or Material: Isosorbide dimethyl ether: Show . In particular, the previously used active ingredients raise significant health concerns, such as the antimicrobials such as triclosan or metal-chelates, or the antipersipant aluminum substances hitherto used for deodorants. The composition according to claim 9 or 10, wherein at least one alcoholic ingredient is contained and is selected from methanol, ethanol, isopropyl alcohol, 1,2-pentadiol, polyethylene glycol and polypropylene glycol, in particular is ethanol, isopropyl alcohol and/or 1,2-pentadiol. Suitable solvent carrier substances include, for example, co-solvents such as water, lower (C. In an embodiment, dimethyl isosorbide is combined with at least one polyol, selected from 1,2-pentadiol, 1,5-pentadiol and polyglycols such as polyethylene glycol and polypropylene glycol. Solubility: soluble in water. even a small amount of water can affect the outcome of the reaction as it can hydrolyse the DMC molecule into CO 2 and methanol . This product is being sent to you as . INCI: Dimethyl Isosorbide Solubility: Soluble in water, propylene glycol, Isopropanol, polysorbate 20 and polysorbate 80 Usage rate:1-50%. Developed by: Clickideas.biz. Hence, with the present invention, a deodorant is provided that is highly effective to reduce body odour, yet is well tolerated especially by the human skin. *We will provide you with commercial invoice, packing list, packing list, COA, health certificate and certificate of origin if you need it. : 5306-85-4 Known for long as a non-toxic and non-irritant substance, and in this sense conventionally used as a solvent or carrier in prior art skin or topic formulations, dimethyl isosorbide as deodorant can beneficially avoid conventional deodorant and antiperspirant active ingredients associated with strong health concerns. Dimethyl Isosorbide As a Green Solvent for Sustainable Ultrafiltration and Microfiltration Membrane Preparation | ACS Sustainable Chemistry & Engineering Solubility soluble in water. Colorescience All Calm Multi-correction Serum ingredients explained: Water/Aqua, Glycerin, C13-15 Alkane, Dimethyl Isosorbide, Niacinamide, Triethylhexanoin, Caprylic/Capric Triglyceride, Sorbitan Stearate, Polyglyceryl-2 Diisostearate, Disodium Lauriminodipropionate Tocopheryl Phosphates, Polyacrylate Crosspolymer-6, Bisabolol, Sorbityl Laurate, Cetyl Palmitate, Tremella Fuciformis Sporocarp . Description: Dimethyl isosorbide is a clear liquid. Functions: Primarily works as a solvent, and secondarily as a viscosity decreasing (reducing thickness) agent. Is a clear, slightly oily-feeling liquid that functions as a solvent and may be plant-based or synthetic. It is a solvent for active ingredients especially DHA for sunless tanning products. For high-value products, please choose air and express to ensure the safety of the products. China Manufacturer of high-quality Organic Intermediate, Food Additives, Inorganic Chemistry, Dyestuffs And Pigments, Fragrance And Spices. Conventional deodorant compositions however suffer from significant drawbacks. Dimethyl isosorbide | C8H14O4 | CID 62990 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . Solvent carriers may also enhance or prolong the deodorant and/or antiperspirant activity of dimethyl isosorbide. Soluble in: alcohol : water, 5.246e+005 mg/L @ 25 C (est) Organoleptic Properties: Odor and/or flavor descriptions from others (if found). It's ability to penetrate deep layers of the skin enables these actives penetrate deeper and work better. Sunless tanners, facial and eye-zone treatments, skin serums, anti-acne formulations, and make-up removers are just some of the products whose performance can be improved with the use of Dimethyl Isosorbide (DMI) in the formulation. You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. Better Cosmetics via Science-based Formulation using Hansen Solubility Parameters (HSP) So you need to know if your cosmetics ingredients are mutually compatible, or you need to optimize the solubility of a key active or want to know if ingredients are compatible with the skin. Dimethyl Isosorbide is soluble in a variety of ingredients including water, cottonseed oil, isopropanol, isopropyl myristate, propylene glycol, polysorbate 20, and polysorbate 80. Penetrant and carrier. * Each batch of products will be tested to ensure that its quality meets user needs. One type of active ingredients aim at controlling bacterial growth on the skin to be treated, since it is known that bacterial breakdown of perspiration substances cause bad odour, predominantly by releasing 3-methyl-2-hexeneoic by the bacterial's waste. The CAS register number of Isosorbide dimethyl ether is 5306-85-4. LOW Cancer LOW Allergies & Immunotoxicity LOW Developmental and Reproductive Toxicity LOW Use Restrictions Ingredient concerns (b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards. The other substances of the deodorant formulation or composition of the present invention are chosen from the substances described above, optionally and beneficially excluding the undesirable substances mentioned above also. 1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol; Risk Liquidform: flammable material; irritation, irritation to skin, eye, respiratory system. Solubility Information: Solubility in water: soluble. Therefore, deodorants are often formulated with antimicrobials such as triclosan, or with metal-chelating agents which slow down bacterial growth. GHS (Rev.9 . Another type of active ingredients aim at exerting an antiperspirant activity. Appearance: liquid Dimethyl isosorbide is an ideal solvent for the cosmetics industry. INCI name: DIMETHYL ISOSORBIDE. Solubility Soluble in water. GB/T 13173 Surface active agents - Detergents - Testing methods, Safety and Technical Standards for Cosmetics (2015 Edition), GB/T 30799 The test method of food detergents - Determination of heavy metals, GB/T 30797 The test method of food detergents - Determination of total arsenic. It is insoluble in hydrogenated castor oil, lanolin, mineral oils or silicone oil (dimethicone). Granactive ACNE is a botanical complex containing a patented antimicrobial peptide for use in products associated with treating acne symptoms. The use or composition according to claim 5, wherein the co-solvent is selected from water and low-molecular (C1-C6) alcohol; and wherein the viscosity-adjusting agent is selected from diols, preferably pentane-diols, polyethylene glycol and polypropylene glycol. Partition coecient, log Pow @ 25 C-1.62 Autoignition Maximum solubility of each drug was found to occur near a DMI/water or DMI/PG concentration ratio of 1:2. Dimethyl isosorbide. It is employed as a specialty solvent. After the samples are approved by the department and users, we will start mass production. Characteristics excellent cleansing, dispersing, emulsifying, solubilizingabilities. After the encapsulation, both compounds significantly prolonged the half-life stability against UV irradiation. In preferred embodiments, the deodorant of the present inventions consists only of dimethyl isosorbide and optionally water and a substance selected from monohydric and dihydric alcohols; and further optionally metal salts such as aluminum salt compounds. Penetration power of DMI is another key advantage when using DMI, because it not only improves penetration of actives into the skin but also, it helps the . A deodorant formulation is prepared as follows: The formulation is used as a deodorant to be applied topically on the skin, for example by spraying with a conventional dispenser device. This capacity of dimethyl isosorbide is unexpected, because albeit it has conventionally been applied as a (co-)solvent to be combined with active ingredients, for example for solubilising skin active ingredients or for promoting their penetration into or through the skin, and therefore has been conventionally used in formulations to increase the effectiveness of the active ingredient, it has not been identified as an active compound or its own for preventing or reducing bad body odour. * Sometimes referred to as Arlasolve DMI or DMI. DMI has extremely low toxicity and facilitates the penetration of active ingredients through the epidermis. Use of dimethyl isosorbide as an active deodorant agent in cosmetic skin applications. Viscosity controlling : Increases or decreases the viscosity of cosmetics. sds. Preferred compositions comprise dimethyl isosorbide, co-solvent e.g. The results . The optional alcohols being preferably selected from methanol, ethanol, 1,2-pentadiol, polyethylene glycol and polypropylene glycol, in particular ethanol and/or 1,2-pentadiol. Dimethyl Isosorbide also known as Epidev, offers a safe, penetration enhancer for active ingredients in personal care formulations. Dimethyl Isosorbide (DMI) Dimethyl Isosorbide CAS: 5306-85-4. It consists of a double transesterification assisted by basic catalysts which promote the abstraction of the isosorbide alcoholic . *We will monitor the logistics information in real-time and will share the information with you. Keep away from oxidizing agents. Purity: 99% Shop Isosorbide dimethyl ether, 99%, Thermo Scientific at Fishersci.com PubChem . The use or composition according to claim 1, 2 or 3, wherein the dimethyl isosorbide is used without any one of the following active agents: other antiperspirants, other germicides; odor-absorbers; enzyme inhibitors; metal-chelating agents; and aluminum compounds. (a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight. The object of the present invention therefore was to provide an improved deodorant by providing a new concept to reduce body odour. Harmful products of combustion are CO, CO2 and so on. Publication types Comparative Study MeSH terms These compounds have been encapsulated by nanoprecipitation into kraft lignin nanoparticles using eco-certified dimethyl isosorbide as a primary solvent and deionized water as an antisolvent. 5306-85-4 - Manufacturer, Supplier, Exporter Moreover, the deodorant according to the present invention may beneficially exclude germicide actives other than dimethyl isosorbide, thereby preferably excluding other anti-bacterial, anti-viral and anti-fungal active agents. The results below support the claim that Dimethyl Isosorbide (Arlasolve DMI) enhances delivery into the epidermis but does not promote the product into the bloodstream. Maximum solubility of the drugs occurred near a dimethyl isosorbide/water or dimethyl isosorbide/propylene glycol concentration ratio of one to 2. Additional information. Synergistic preservative systems and their use in topical compositions. In the DMI-PEG mixed system, while there is no apparent interaction between DMI and PEG molecules, the solubility of prednisone was found to increase with decreasing dielectric constant. If your market has other special requirements, please let us know. All rights reserved. 5306-85-4, We will provide you with detailed information and satisfactory service. It is a solvent for active ingredients especially DHA for sunless tanning products. Application in the field of Medicine: plaster, tincture, etc. Solubility (other) No data available. Cosmetic Information: . Chim., 2011, 62, 401-408 2011. The ability to transport water soluble actives into skin. Ask us anything. It has been found that dimethyl isosorbide can effectively penetrate the skin, because it has the ability to dissolve loose fat in the skin so that it can carry across the skin membrane. It has shown interesting properties in the delivery of substances like lactic acid, hydrocortisone, vitamin C, and hyaluronic acid. The solubilization behavior of DMI as a cosolvent for nonpolar drugs was characterized via dielectric constant measurements of binary solvent systems containing DMI and either water . Stability stable. Please contact us. Therefore, it is the preferred solvent. (Dimethyl Isosorbide) DATE PREPARED: 12/21/2016 Page 1 of 5 Section 1. Give your inbox a healthy dose of fun and well-being. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements. It also can be called as 1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol and the IUPAC name about this chemical is 3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro [3,2-b]furan. Isosorbide | C6H10O4 | CID 12597 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Dimethyl isosorbide (DMI) is a sustainable alternative to dipolar aprotic solvents such as NMP and DMF, suitable for organic synthesis, as Baylis-Hillman reaction, and due to its high solubilization capacity when used as co -solvent for nonpolar drugs, make it an interesting compound for pharmaceutical and cosmetic industries as well. It is insoluble in hydrogenated castor oil, lanolin . The following examples may illustrate the present invention without however being limited thereto. Contact with strong oxidants, can cause to burn. Isosorbitol dimethyl ether (DMI) applied in cosmetics: can significantly enhance the effect of sunscreen, anti-wrinkle, freckle, acne, skin care and moisturizing, weight loss, breast cream, hair agent, hair dye and other products, is the ideal solvent in the cosmetics industry. It is also used to decrease the thickness of products, such as keeping a liquid in its fluid form rather than allowing it to reverse to a lotion. The most preferred site of administration are the armpits and the feet of humans. DMI . Free format text: Shop Isosorbide dimethyl ether, 98%, Thermo Scientific at Fishersci.ca Solubility:Soluble in water, isopropanol, isopropyl myristate, propylene glycol, polysorbate 20, and polysorbate 80 It is insoluble in hydrogenated castor oil, lanolin, mineral oils and silicone oil (dimethicone). ORIGINAL CODE: 0009012, Kind code of ref document: A composition consisting of dimethyl isosorbide and water, and optionally at least one substance selected from the following group of ingredients: monohydric and polyhydric alcohols; metal salts; perfumes; colouring agents; oils and paraffins; triglycerides; surfactants; and other conventional skin-care carrier substances without pharmacologic activity. Other Names: DMI Given its newly identified activities, it is to be appreciated that the use of dimethyl isosorbide as deodorant or in deodorant formulations does not suffer from drawbacks of conventionally used active ingredients or prior deodorant formulations. Dimethyl Isosorbide is a dimethyl ether of an anhydride of an isomer of sorbitol. Some documentation and label information may refer to the legacy . Improved shelf stability of active ingredients, including actives susceptible to hydrolysis and transesterification isosorbide is a diol readily obtained from starch that can be used as a polar building block for the synthesis of derivatives ranging from solvents to surfactants: dime-thyl isosorbide (dmi) is. The best possible outcomes customer requirements highly miscible with most surfactants, co-solvents colorants. Listed. share the information with you agent in cosmetic skin applications reply and 24 hours online, the isosorbide-PEG! 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Harmful products of combustion are CO, CO2 and so on decreasing dielectric constant reducing thickness ) agent excluded! And thereby becoming useless to the present invention may dimethyl isosorbide solubility in water enhance or prolong the deodorant antiperspirant Cleansing, dispersing, emulsifying, solubilizingabilities within 24 hours online, the composition Dimethyl!