#shippingMessageInsideBuyBox_feature_div>.a-letter-space{display:none!important}#shippingMessageInsideBuyBox_feature_div>.a-section{display:inline-block!important} However, recent studies of oral tranexamic acid in treating hyperpigmentation and melasma have been quite promising. As an off-label prescription, oral tranexamic acid at a low dosage has been used to slow melanin synthesis to treat melasma. In addition to tranexamic acid, the serum contains several additional brightening actives to support the effects of tranexamic acid: #ib-text-links-content{text-transform:uppercase}#ib-text-links-content ul li:not(:first-child){margin-left:15px}#ib-text-links-content ul li{display:inline-block;padding:6px 0 24px}#ib-text-links-content.text-link-style-space{min-height:50px}#ib-text-links-content.show-button ul{display:flex;display:-webkit-flex;justify-content:center;-webkit-justify-content:center}#ib-text-links-content.show-button ul li:not(:first-child){margin-left:15px}#ib-text-links-content.show-button ul li{display:inline-block;padding:6px 0 9px;width:100%;max-width:50%}#ib-text-links-content .a-button-text{text-transform:uppercase}#ib-text-links-content .a-button-focus{border-color:#adb1b8 #a2a6ac #8d9096;box-shadow:none;-webkit-box-shadow:none}#ib-text-links-content .a-button{border-color:#0066c0;width:100%}#ib-text-links-content .a-button-inner{background:#fff}#ib-text-links-content .a-button-text{color:#0066c0}#imageblock-360view-textlink:not(:only-child){width:auto!important;max-width:none!important;flex:1}#ar-view-text-link:not(:only-child){width:auto!important;max-width:none!important;margin-left:15px;flex:1.5}#imageblock-360view-textlink:only-child{max-width:100%!important;width:auto!important}#imageblock-360view-textlink:only-child #image-block-360-button #fezCameraIconContainer{max-width:100%;min-width:0;width:auto;text-align:center}#ar-view-text-link:only-child{max-width:100%!important;width:auto!important}#ar-view-text-link:only-child #fezLauncherLink #fezCameraIconContainer{max-width:100%;min-width:0;width:auto;text-align:center}#imageblock-360view-textlink #image-block-360-button{height:100%}#imageblock-360view-textlink #image-block-360-button #fezCameraIconContainer{display:flex;height:100%;align-items:center;justify-content:center;margin:0 auto;width:max-content}#imageblock-360view-textlink #image-block-360-button #fezCameraIconContainer img{vertical-align:middle;margin-right:6px;min-width:20px;max-width:20px}#imageblock-360view-textlink #image-block-360-button-announce{height:100%}#ar-view-text-link #fezLauncherLink-announce{height:100%}#ar-view-text-link #fezLauncherLink{height:100%}#ar-view-text-link #fezLauncherLink #fezCameraIconContainer{display:flex;height:100%;align-items:center;justify-content:center;max-width:fit-content;text-align:left;margin:0 auto;width:min-content;min-width:100%}#ar-view-text-link #fezLauncherLink #fezCameraIconContainer img{vertical-align:middle;margin-right:6px;min-width:16px;max-width:16px}#ar-view-text-link #fezLauncherLink #fezCameraIconContainer:lang(es-us){min-width:50%}.image-wrapper{position:relative}.ar-ib-ingress-container{position:absolute;width:calc(100vw - 32px);left:50%;top:50%;transform:translate(-50%,-50%);display:flex;flex-direction:column;max-height:100%;overflow:hidden}.ar-ib-ingress-container #ar-ib-ingress-heading-text,.ar-ib-ingress-container #ar-ib-ingress-subheading-text{display:-webkit-box;-webkit-line-clamp:2;-webkit-box-orient:vertical;overflow:hidden;margin-bottom:8px}.ar-ib-ingress-container .text-content{color:#fff}.ar-ib-ingress-container #ar-ib-ingress-image{background-size:contain;background-repeat:no-repeat;background-position:center;width:100%;max-height:136px;flex-basis:136px}.ar-ib-ingress-container .ar-ib-ingress-btn{width:fit-content;height:32px;max-width:calc(100% - 80px);margin-bottom:8px}.ar-ib-ingress-container .ar-ib-ingress-btn .a-box-inner{justify-content:center;display:flex;align-items:center;text-align:center;height:30px;vertical-align:middle}.ar-ib-ingress-container .ar-ib-ingress-btn .a-size-small{display:-webkit-box;-webkit-line-clamp:1;-webkit-box-orient:vertical;overflow:hidden;text-align:left;line-break:anywhere}.ar-ib-ingress-container .ar-ib-ingress-btn .icon{padding-left:16px;padding-right:8px;vertical-align:middle}.ar-ib-ingress-container .ar-ib-ingress-btn .content{padding-right:16px}.ar-ib-ingress-overlay{position:absolute;opacity:.6;background:#000;height:100%;width:calc(100vw - 16px);top:50%;left:50%;transform:translate(-50%,-50%)}#dyr-ingress-content .a-button-text{text-transform:uppercase}#dyr-ingress-content ul{display:flex;display:-webkit-flex;justify-content:center;-webkit-justify-content:center}#dyr-ingress-content ul li:not(:first-child){margin-left:15px}#dyr-ingress-content ul li{display:inline-block;padding:6px 0 9px;width:100%;max-width:60%}#dyr-ingress-content .a-button-focus{border-color:#ADB1B8 #A2A6AC #8D9096;box-shadow:none;-webkit-box-shadow:none}#dyr-ingress-content .a-button{border-color:#0066c0;width:100%}#dyr-ingress-content .a-button-inner{background:#fff}#dyr-ingress-content .a-button-text{color:#0066c0} Chung JY, Lee JH, Lee JH. Additional large, double-blinded, controlled trials are needed to thoroughly assess the role of intradermal TA. 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After eight and 12 weeks, MASI scores were decreased. The article was selected as a "game changer" study in the Oct. 30, 2018 issue of the Journal of the American Academy of Dermatology. A: In melasma, the hypothesised mechanism of action of tranexamic acid includes the shrinkage of dermal vasculature and reduced melanin synthesis by altering the interaction of keratinocytes and melanocytes and reducing tyrosinase activity [1,2]. .media-matrix-full-bottom-sheet{padding:10px}.full-bottom-sheet-scroller-content{padding:0;white-space:nowrap}.full-bottom-sheet-item-scroller-content{padding:0;margin-top:8px;max-width:100%;white-space:nowrap;overflow-x:scroll;overflow-y:hidden}.full-bottom-sheet-skeleton-swatch-label{width:120px;height:16px;background-color:#d3d3d3}.full-bottom-sheet-swatch-scroller-content{padding-bottom:8px;max-height:100%;max-width:100%;margin-top:8px;overflow-x:scroll}.full-bottom-sheet-skeleton-swatch{padding:10px;margin-bottom:10px;width:120px;height:56px;max-height:56px;border:solid 2px #d3d3d3}.full-bottom-sheet-skeleton-swatch-title{width:80px;height:16px;background-color:#d3d3d3}.full-bottom-sheet-skeleton-item-label{margin-top:10px;width:120px;height:16px;background-color:#d3d3d3}.full-bottom-sheet-skeleton-item{padding:10px;margin-bottom:10px;width:202px;max-width:202px;height:292px;max-height:292px;border:solid 2px #d3d3d3}.full-bottom-sheet-skeleton-item-image{height:200px;width:100%;background-color:#d3d3d3}.full-bottom-sheet-skeleton-item-price{margin-top:10px;width:75px;height:20px;background-color:#d3d3d3}.full-bottom-sheet-audible-icon{width:20px;margin-top:2px}#media_matrix_item_buttons a{padding:8px!important}.full-bottom-sheet-section{padding:0;margin:0}.full-bottom-sheet-format-label{padding:0;margin-left:5px;margin-bottom:0;text-align:left;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.full-bottom-sheet-swatch{min-width:120px;margin-top:0;margin-bottom:0;height:59px;max-height:59px;text-align:left;vertical-align:top}.full-bottom-sheet-badge{vertical-align:center}.full-bottom-sheet-swatch-extra-message{padding-left:5px;min-height:0;max-height:42px;min-width:120px;line-height:1.3em!important;white-space:normal;overflow:hidden;text-overflow:ellipsis;display:block}.full-bottom-sheet-swatch-title{text-align:left}.full-bottom-sheet-item-label{padding:0;margin-top:10px;margin-left:5px;margin-bottom:0;text-align:left;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.full-bottom-sheet-item-button{width:202px;max-width:202px;min-height:278px;height:100%;max-height:100%}.full-bottom-sheet-hidden-buttons{display:none}.full-bottom-sheet-displayed-buttons{display:initial}.full-bottom-sheet-item-button-content{padding:8px}.full-bottom-sheet-one-line-text-field{margin-bottom:5px;margin-left:0;margin-right:0;height:14px;width:100%;max-height:14px;max-width:100%;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.full-bottom-sheet-two-line-flex-text-field{margin-top:5px;margin-bottom:5px;margin-left:0;margin-right:0;height:28px;width:100%;max-width:100%;line-height:1.3em!important;white-space:normal;overflow:hidden;text-overflow:ellipsis;display:block}.full-bottom-sheet-four-line-text-field{margin-bottom:7px;margin-left:0;margin-right:0;margin-top:0;height:62px;width:100%;max-height:62px;max-width:100%}.full-bottom-sheet-item-price{margin-bottom:5px}.full-bottom-sheet-item-image-container{text-align:center;margin-bottom:5px;height:120px;max-height:120px;max-width:100%;margin-left:0;margin-right:0;background-color:#d3d3d3}.full-bottom-sheet-item-image{text-align:center;vertical-align:center}.mm-secondary-view-skeleton-title{margin-top:10px;margin-bottom:10px;width:50%;height:28px;background-color:#a9a9a9}.mm-secondary-view-skeleton-list-item{height:45px}.mm-secondary-view-skeleton-row-title{margin-top:11px;margin-left:11px;width:50%;height:23px;background-color:#d3d3d3;border-radius:3px;text-align:left;vertical-align:middle;position:absolute;display:inline-block}.mm-secondary-view-skeleton-row-radio{margin-top:10px;margin-right:10px;position:relative;float:right;vertical-align:middle;border-radius:50%;width:25px;height:25px;border:2px solid #a9a9a9} Free delivery for many products! };
, Your information will be stored to send you emails. This seems to suggest that the effects of oral tranexamic acid were independent of the type of topical therapy used, they wrote. The exact mechanisms tranexamic acid employs to reduce pigmentation is actually unclear, Dr. Chang notes. Some reported side effects include: abdominal pain bloating nausea and vomiting itchy or numb face tinnitus. 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